The purpose of this investigation was to evaluate the antigenic level and functional activity of protein C, protein S and free protein S in various thrombogenic disease states. Also, the study on the reference values of protein C and protein S in
normal
Korean adults was included.
@ES The results were summarized as follows;
@EN 1. The antigenic level and functional activity of protein C in normal Korean male were 100±20.9%(mean±2SD), 99.9±22.8% and those in female 97.4±18.4% 97.4±24.2%. Those of difference. The average antigenic level and functional activity of
normal
Korean adults were respectively 99.0±20.1% and 98.9±23.6%. The antigenic level and functional activity of protein S in normal Korean male were 102.8±23.7%, 104.6±16.2% and those in female 99.5±26.7%, 99.3±31.3%. The female showed
significantely
lower value than male (p<0.05).
The average were 100.7±25.4%, 102.6±28.6%, Free protern S antigenic level were 42.4±11.4% in normal male and 40.3±12.3% in normal female. The female showed little lower value than the male, but it was not statistically different. The average
was
41.5±12.1%.
2. Protein C antigenic level and functional activity decreased very significantly in toxemia (84.8±8.5%, 80.6±15.3%), chronic liver diseases (44.6±19.3%, 43.6±19.0%), disseminated intravascular coagulopathy (54.7±19.4%, 53.3±19.1%),
hepatoma,
acute and chronic
myelogenous leukemia, malignant lymphoma and lung cancer (66.9±58.6%, 65.7±62.2%) (p<0.001), but showed no change in acute lymphoblastic leukemia, stomach, colon and ovarian cancers. Protein S antigenic level and functional activity decreased
very
significantly in normal pregnancy (67.9±18.6%, 50.1±22.4%), toxemia (66.3±8.5%, 61.7±25.3%), chronic liver diseases (62.8±12.2%, 62.9±12.9%), disseminated intravascular coagulopathy (67.2±13.1%, 67.5±11.7%), toxemia, acute and chronic
myelogenous leukemia, malignnat lymphoma, lung cancer(p<0.001), and significantly decreased in acute lymphoblastic leukemia (94.5±30.9%, 96.2±35.1%), but showed no change in stomach, colon and ovarian cancers. Free protein S antigenic level
very
significantly decreased in normal pregnancy (21.9±9.2%), toxemia (24.8±14.6%), chronic liver diseases (22.4±5.0%), disseminated intravascular coagulopathy (22.7±4.2%), hepatoma, acute and chronic myelogenous leukemia, malignant lymphoma and
lung
cancer (33.3±24.1%) (p<0.001), but showed no change in stomach, colon and ovarian cancers.
3. There was good correlation between protein C antigenic level and functional activity, and between protein S antigenic level functional activity(r>0.6).
Our results showed the decreased antigenic level and functional activity of protein C and S, and free protein S antigenic level in various thrombogenic disease states except few non-hematologic malignancy. Such results might be helpful to
understanding
the pathogenesis of thrombogenic phenomena in various diseases and might be useful guide to therapeutic management.
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